For many women with bipolar disorder, lamotrigine (Lamictal) is an effective mood stabilizer. Given its favorable reproductive safety profile, lamotrigine is a reasonable option for women who require treatment with a mood stabilizer during pregnancy.
Can you take Lamictal when pregnant?
The FDA-approved prescribing information says that lamotrigine “should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.” The “potential benefit” is generally the mother’s mental health condition.
Can Lamictal cause birth defects?
A study published last year in the journal Neurology also found that babies born to pregnant women taking lamotrigine appeared not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot.
Can Lamictal cause a miscarriage?
There is currently no proof that lamotrigine use in pregnancy causes miscarriage or stillbirth.
Why is lamotrigine safe in pregnancy?
Although lamotrigine is commonly prescribed and has a good safety profile, a study in 2008 in the Neurology journal reported that lamotrigine exposure increased the frequency of congenital anomalies such as cleft palate in babies [Holmes L et al., 2008].
Does Lamictal cross the placenta?
The study, which assessed neurodevelopmental symptoms up to the age of 12 years, is the most extensive long term report regarding children whose mothers took lamotrigine during pregnancy. Lamotrigine has a good tolerability and safety profile, but is known to cross the placenta.
Does Lamictal make it hard to get pregnant?
There’s no firm evidence that lamotrigine affects female fertility. For some men with epilepsy, epilepsy medicines can reduce their levels of testosterone. It does not affect everyone, but it could make you less fertile.
Which mood stabilizers are safe during pregnancy?
Data for lamotrigine (LTG) appears to be more favorable than other antiepileptics. During lactation, use of valproate and LTG is reported to be safe. Use of typical and/atypical antipsychotic is a good option during pregnancy in women with bipolar disorder.
Does Lamictal deplete folic acid?
Anticonvulsants that do not induce cytochrome P450 enzymes, such as lamotrigine (Lamictal), are not associated with low levels of folic acid.
Can you breastfeed while on lamotrigine?
The results indicated that lamotrigine is a safe anti-epileptic drug for breastfeeding women with rare and usually mild adverse effects among neonates exposed to high milk concentration of this drug and its metabolites.
How safe is lamotrigine?
Lamotrigine (Lamictal) has been associated with a rare, but serious and life-threatening adverse reaction called hemophagocytic lymphohistiocytosis (HLH), which can lead to multi-organ failure resulting in hospitalization or death, particularly if diagnosis and treatment are delayed.
What happens if you drink alcohol while on lamotrigine?
Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with lamoTRIgine.
Can pregnancy make bipolar worse?
Bipolar disorder, however, can worsen during pregnancy. Pregnant women or new mothers with bipolar disorder have seven times the risk of hospital admissions compared to pregnant women who do not have bipolar disorder.
What class drug is Lamictal for pregnancy?
AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.
What does Lamictal do?
Lamotrigine is used alone or with other medications to prevent and control seizures. It may also be used to help prevent the extreme mood swings of bipolar disorder in adults. Lamotrigine is known as an anticonvulsant or antiepileptic drug.
Can lamotrigine affect periods?
Tell your doctor right away if you have unusual changes in your menstrual cycle such as breakthrough bleeding while taking lamotrigine and birth control pills or other female hormonal products.